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KMID : 0358819780050010045
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1978 Volume.5 No. 1 p.45 ~ p.50
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Effects of Prednisolone and Vitamin A on Open Wound Healing in Rabbits
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Abstract
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Anti-inflammatory steroids such as prednisolone acetate delay healing of open wounds. Many attempts have been made to interpret this phenomenon, but no satisfactory explanation has been found.
Antiinflammatory steroids increase the integrity of the lysosome, the subcellular particle which contains an assortment of acid hydrolases, but vitamin A labilize the integrity of it. Vitamin A and prednisolone acetate have antagonistic effects upon the lysosomal membrane.
This experiment was designed to study the effects of vitamin A and prednisolone acetate on wound healing.
Standardized flank wounds were made on 20 rabbits divided into the following 4 groups : Group I served as controls, Group 2 were given prednisolone acetate 1mg. /kg. /day (I. M), Group 3 vitamin A 500 1. U. /kg. /day (L M. ), Group 4 vitamin A 500 I. U. /kg/day and prednisolone acetate 1mg. /kg. /day.
Wound contracture and epitheliza*ion were measured by planimetry of sterile cellophane taken twice weekly. The outline of the wound was traced as accurately as possible on a superimposed sheet of cellophane. This outline was then transferred directly to sheet of graph and the area within it was counted.
Prednisolone acetate decreased the total amount of contracture and rate of epithelization. Vitamin A alone did not increase the rate of contracture and epithelization over control levels but has shown to overcome the inhibitory effects of prednisolone acetate on the rate of epithelzation and contracture of open wound.
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